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BroadPharm

BroadPharm

更新时间:2024-03-11

访问量:45

厂商性质:代理商

生产地址:

简要描述:
品牌:BroadPharm是一个的以客户为中心的生物技术公司,总部位于圣地亚哥,BroadPharm致力于为客户提供高质量的PEG接头、ClickChemistry试剂、ADC接头、PROTAC接头、药物递送脂质、核苷、亚磷酰胺和标记试剂


品牌: 


BroadPharm是一个的以客户为中心的生物技术公司,总部位于圣地亚哥,BroadPharm致力于为客户提供高质量的PEG接头、Click Chemistry试剂、ADC接头、 PROTAC接头、药物递送脂质、核苷、亚磷酰胺和标记试剂。BroadPharm成立于2009年,生产超过2000种分散的,高纯度的聚乙二醇(PEG)试剂,目前这些PEG试剂广泛应用于生物偶联、抗体-药物偶联(ADC)治疗、药物递送和诊断领域。


主要产品线:

  • PEG接头

  • 点击化学试剂

  • 标记染料

  • ADC接头

 

1. PEG接头(PEG linker

PEG连接剂,也称为PEG试剂,是一种化学功能化的聚乙二醇(PEG)连接剂。由于其水溶性、无毒性、低免疫原性和明确的链长,PEG连接剂作为交联剂在偶联和生物标记方面特别有吸引力。 

PEG化是将PEG连接体连接到药物、蛋白质或囊泡等分子上的过程。由于其高水溶性和非免疫原性,PEG已被广泛用于制药和生物技术研发,以提高药物的溶解度和稳定性,优化DMPK并发现新的递送形式。BroadPharm的PEG-Linker代表一种高纯度的特定单一纯分子,这些单分散PEG是用设计的PEG长度和各种官能团设计的。 


BroadPharm能够提供的PEG接头类型: 


PEG接头的结构: 


2.点击化学试剂(Click Chemistry):

点击化学已广泛应用于制药和生物技术研发。在代Click Chemistry,是在末端炔烃和叠氮化物之间的反应中需要Cu(I)作为催化剂。Cu(I)离子的毒性会对生物分子造成氧化损伤。第二代Click Chemistry采用应变促进叠氮-炔Click Chemistry,无需催化剂,具有生物相容性。与末端炔烃相比,应变环辛烯的活化能显著降低。第三代Click Chemistry是四嗪和烯烃(反式环辛烯)之间的连接。这种高速反应也是不含铜的,这是体内细胞标记的理想选择。    


BroadPharm可提供的点击化学试剂类型:   


3.标记染料:

荧光试剂已被用于标记蛋白质、抗体、核酸和其他生物物质,用于生物标记、细胞成像、诊断、蛋白质印迹和免疫组织化学。荧光染料可以连接到氨基(N)或羧基(C)末端,或者通过点击化学进行连接。  


BroadPharm可以提供的荧光基团类型:   


4.ADC接头: 

抗体药物结合物(ADC)是一类由抗体通过适当的连接子/接头与药物负载物链接在一起的高效生物药物。连接剂分为可降解和不可降解两个家族。         

① 可降解连接剂的ADC,以Adcetris(由Seattle Genetics推出)代表,其结构如下所示:   

② 对于不可降解连接剂的ADC,它依赖于ADC内部化后抗体的降解,以Kadcyla代表(由Genentech和Roche推出),其结构如下所示:     

作为BroadPharm在中国的区域总代理,科技有限公司将为中国客户提供全面的BroadPharm的产品。下图为BroadPharm公司科技有限公司(AmyJet Scientific Inc.)作为BroadPharm在中国区域的代理书。

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作为BroadPharm在中国的区域总代理,科技有限公司将为中国客户提供全面的BroadPharm产品以及客户订制化服务,欢迎大家随时联系我们。


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